Spur Therapeutics

Spur Therapeutics is a clinical-stage biotechnology company focused on developing life-changing gene therapies for debilitating chronic conditions.

By optimising every component of its product candidates, Spur aims to unlock the true potential of gene therapy to realise outsized clinical results. Spur is advancing a breakthrough gene therapy candidate for Gaucher disease and a potential first-in-class gene therapy candidate for adrenomyeloneuropathy (AMN), as well as a research strategy to move gene therapy into more prevalent diseases, including forms of Parkinson’s, dementia, and cardiovascular disease.

Spur’s lead programme, FLT201, is a highly differentiated gene therapy candidate that delivers a novel transgene to treat Gaucher disease Type 1, for which there is currently no cure. Spur’s next generation gene therapy uses AAV technology that aims to deliver best-in-class safe and effective gene replacement to the liver to produce sustained therapeutic protein expression. Spur has additional pre-clinical research programmes in central nervous system (CNS) and cardiovascular diseases, including one focused on GBA1 Parkinson’s disease that leverages the same novel transgene as FLT201.

In 2024 Spur acquired Syncona portfolio company SwanBio Therapeutics, creating a consolidated adeno-associated virus (AAV) gene therapy pipeline, bringing synergies around clinical capabilities and manufacturing know-how, as well as driving cost and operating efficiencies. Through acquiring SwanBio, Spur incorporated SBT101, a potentially first-in-class AAV gene therapy in Phase I/II clinical trials for the treatment of AMN, into its pipeline. AMN is a devastating neurodegenerative disease for which there are currently no approved treatments. The integration of the SBT101 programme enhances Spur’s growing focus on CNS disorders, including for its pre-clinical research programme in Parkinson’s.